Please explore a collection of articles and videos related to MiDR1V3. We will update these as the science evolves.
RESOURCE HUB
| Category | Title | Authors | Journal | Summary |
| Clinical Trials of Ketone-Based Interventions | Open-label trial of (R)-1,3-butanediol | Lowder et al., 2023 | Front. Physiol. | Assesses ketone levels, GI tolerability, and sleepiness |
| Clinical Trials of Ketone-Based Interventions | Salt-free D-BHB safety study | Pimentel-Suarez et al., 2023 | BMJ Nutr Prev Health | Shows tolerability of D-BHB without salts |
| Clinical Trials of Ketone-Based Interventions | Ketogenic MCT drink in MCI | Fortier et al., 2019 | Alzheimer's Dement | Improves brain energy and cognition in MCI |
| Clinical Trials of Ketone-Based Interventions | MCTs improve MMSE in elderly | Abe et al., 2020 | J Nutr | 6g/day MCTs improved cognition in frail older adults |
| Clinical Trials of Ketone-Based Interventions | Ketogenic diet in Parkinson's | Tidman et al., 2024 | Neurodegener Dis Manag | Longitudinal improvement in PD symptoms and quality of life |
| Functional Network Imaging & Brain Aging | Functional brain networks in neurodegenerative disorders | Perovnik et al., 2023 | Nat Rev Neurol | Network tools used to identify disease patterns and track progression |
| Functional Network Imaging & Brain Aging | Functional brain networks and treatment in PD | Barbero et al., 2023 | Neurotherapeutics | Treatment-induced networks serve as biomarkers in PD |
| Functional Network Imaging & Brain Aging | Longitudinal metabolic network changes in AD | Perovnik et al., 2023 | Alzheimer's Dement | ADRP expression increases predict conversion to dementia |
| Functional Network Imaging & Brain Aging | Brain aging nonlinear shifts show midlife window | Antal et al., 2025 | PNAS | Ketones restore network stability during critical midlife window |
| Mechanisms of Action & Brain Energy Metabolism | Mechanisms of ketogenic diet action | Masino & Rho | Jasper's Basic Mechanisms of Epilepsies | Comprehensive explanation of ketone effects on brain |
| Mechanisms of Action & Brain Energy Metabolism | Glucose-sparing action of ketones | Zilberter & Zilberter, 2020 | eNeuro | Ketones free up glucose for NADPH, neurotransmitters |
| Mechanisms of Action & Brain Energy Metabolism | Why brain avoids fatty acid oxidation | Schanfeld & Reiser, 2013 | J Cereb Blood Flow Metab | Fatty acid oxidation is oxygen costly, slow, and ROS-generating |
| Metabolic Interventions in Parkinson's | NADPARK trial: Nicotinamide riboside in PD | Brakedal et al., 2022 | Cell Metab | NR increases NAD and improves brain metabolism in PD |
| Redefining Health & Systems Biology | Why we focus on disease more than health | Picard | N/A | Calls for redefining health around systems energy regulation |
| Redefining Health & Systems Biology | Mitochondria in health and disease | San-Millan, 2023 | Antioxidants | Sedentarism as mitochondrial dysfunction and disease driver |
| Redefining Health & Systems Biology | Energy Homeostasis Principle | Vergara et al., 2019 | Front. Comput. Neurosci. | Neuronal networks driven by energy availability |
| Systematic Reviews and Ketone Therapeutic Perspectives | Ketones for neurodegenerative diseases | Norwitz et al., 2020 | Int Rev Neurobiol | Outlines BHB roles in AD and PD therapy |
| Systematic Reviews and Ketone Therapeutic Perspectives | Ketogenic interventions in MCI/AD/PD | Bohnen et al., 2023 | Front. Neurol. | Graded evidence of cognitive and metabolic outcomes |
| Systematic Reviews and Ketone Therapeutic Perspectives | Veech hypothesis on ketone metabolism | Veech, 2004 | Prostaglandins Leukot Essent Fatty Acids | Details redox, energy yield, and therapeutic logic |
| Systematic Reviews and Ketone Therapeutic Perspectives | Ketones enhance neurofunction | Naithani & Karn, 2020 | Health Scope | Ketones as efficient brain fuel across diseases |
| Women's Brain Health & Endocrine Transitions | Menopause alters brain energy & structure | Mosconi et al., 2021 | Sci Rep | Brain metabolism, connectivity, and amyloid linked to hormonal shifts |
| Women's Brain Health & Endocrine Transitions | Perimenopause and Alzheimer's phenotype | Mosconi et al., 2017 | PLOS ONE | CMRglc and mitochondrial decline during perimenopause |
| Women's Brain Health & Endocrine Transitions | Perimenopause and Alzheimer's phenotype | Mosconi et al., 2017 | PLOS ONE | CMRglc and mitochondrial decline during perimenopause |